Ovelle Cetomacrogol Cream BP (Formula A)

Product Information

Use: Cationic base, emollient, antiseptic. This cream base may be used for incorporating cationic substances such as chlorhexidine, aminoacridine and acriflavinium. Occlusive agents provide a hydrophobic ( lipophilic) layer of oil on the surface of the skin, forming a protective barrier to reduce evaporative water loss from the stratum corneum (the outermost layer of the epidermis). Very dry skin may benefit from a greasy, occlusive moisturiser applied every couple of hours, while slightly dry skin may only need a light moisturiser at night. Exclusion criteria included current requirement for systemic corticosteroids, or systemic corticosteroid treatment in the 4 weeks prior to visit 1, current requirement for oral or topical antibiotic therapy for rosacea, current requirement for topical corticosteroid treatment for rosacea, known or suspected allergy to honey, or Cetomacrogol control cream, or any other condition which, at the investigators discretion, it was believed may present a safety risk or impact the feasibility of the study or the study results.

CETOMACROGOL CREAM BP 1988 FORMULA A - medicines

Care must be taken to avoid contamination during preparation of aqueous creams. The apparatus used and the final containers should be thoroughly cleaned, rinsed in freshly boiled and cooled water, and dried. Purified water used in the preparation of creams should be freshly boiled and cooled before use.Commercial creams have also been utilized as a semi-solid carrier system of phages for topical application [ 34, 35, 40, 41]. These creams are emollients or moisturisers for treating dry skin conditions but have been used for delivery of phages. O’Flaherty et al. (2005) incorporated phage K into an oil-based cream containing bismuth subnitrate (Cross Vetpharm Group Ltd, Ireland) at a final phage concretion of 10 8 PFU/g. The phage cream inhibited the growth of S. aureus in liquid broth culture and on petri dish. Although the antibacterial activity of the phage cream was demonstrated, the phage release profile is unknown. Brown et al. (2016) formulated Propionibacterium acnes phages into a non-ionic cream, cetomacrogol cream aqueous (Biotech Pharmaceuticals, Australia) ( Table 1) [ 34]. Phage stability was achieved when the formulation was stored at 4°C in a light protected bottle (~1 log titer loss). Storage at high temperature (45°C) or exposure to full light at room temperature (20–25°C) caused phage inactivation within 14 and 21 days, respectively.

Cetomacrogol™ 1000 pharma | Croda Pharma Cetomacrogol™ 1000 pharma | Croda Pharma

Agrawal AM, Pandey P. Scale up of pan coating process using quality by design principles. J Pharm Sci [Internet]. Elsevier Masson SAS. 2015;104(11):3589–611. https://doi.org/10.1002/jps.24582.

Skin reactions

Applications per day were analysed by analysis of variance (ANOVA) with the response variable as the mean average number of applications per day, predictor variable randomisation group, and using the number of days in the trial as a weight, to account for variations in the number of days of application. To be sure that all the separated cream components could be visualized, a universal detection method, i.e., flame ionization detection was proposed. More recently, microfluidic devices have been used to produce phage-encapsulated liposomes [ 51, 52]. Microfuidic approaches enable precise control over the size of liposomes – narrow particle size distribution compared to the conventional thin-film hydration method. The size distribution is one of the critical factors that influence drug release profile, loading capacity and liposome stability as well as pharmacokinetics and pharmacodynamics. Leung et al. (2018) used soy phosphatidylcholine:cholesterol (4:1) to encapsulate podovirus and myovirus Pseudomonas phages in liposomes. The lipid mixture was dissolved in ethanol (17.5 mg/mL) and then injected through a cross mixer. The phage suspensions were injected from the side channels intersecting the central channel. Phage encapsulation efficiency of 50–59% was achieved at a total flow rate of 160 µL/min and organic/aqueous flow rate ratio of 2:3. Interestingly, the size of phage-encapsulated liposomes was dependent on the size of the phages. Those encapsulating long-tailed myovirus was bigger (261–448 nm) than short-tailed podovirus-containing liposomes (135–218 nm). Anany H, Chen W, Pelton R, Griffiths MW. Biocontrol of Listeria monocytogenes and Escherichia coli O157:H7 in meat by using phages immobilized on modified cellulose membranes. Appl Environ Microbiol

What is Cetomacrogol cream? How does it work for dry skin

Method: Melt the white beeswax in the liquid paraffin. Separately, warm the purified water to about 70°C, and use it to dissolve the borax. Mix the two phases and stir until cool.Lake OA, Hulshoff A, Indemans AWM (1982) Analysis of creams—III. Application of gas-liquid chromatography. Part I. Pharm Weekbl Sci Ed 4:43–48. https://doi.org/10.1007/BF01963660 Poly(N-isopropylacrylamide-co-allylamine) (PNIPAM-co-ALA) nanospheres for the thermally triggered release of Bacteriophage K. Eur J Pharm Biopharm Method: Melt the cetomacrogol emulsifying wax in the peanut oil at 70°C. Add the chlorocresol to a warmed 200mL container, then add 55mL of just-boiled purified water (>80°C), close the container and shake to dissolve. Mix the two phases, and stir until a semi-solid cream forms. Make up to 93g with warm purified water and mix thoroughly. Stir until cool. Triturate the calamine and zinc oxide with a small portion of the cream, then incorporate the remainder. One method of selecting combinations of emulsifying agents is the hydrophile–lipophile balance system, which uses numerical values to indicate the balance between hydrophilic and lipophilic properties of surfactants. 7 Natural emulsifying agents Cetomacrogol cream is a non-greasy moisturiser for the relief of dry skin conditions. Combining with glycerin enhances the moisturising effect.